R.L. Burnside died September 1, 2005 at a hospital in Memphis.

"Blues artist R.L. Burnside, who redefined the blues genre by incorporating indie rock acts and hip-hop production, died September 1, 2005, at St. Francis Hospital in Memphis, Tennessee. Burnside was born November 21, 1926, in Harmontown, Mississippi, and spent most of his life in the north Mississippi hill country, where he worked as a sharecropper and a commercial fisherman and played guitar at weekend house parties. In 1968, noted folklorist George Mitchell recorded Burnside for the first time."